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histone
(redirected from Histones)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
histone /his·tone/ (his´tōn) a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, e.g., the protein combined with nucleic acid or the globin of hemoglobin.
his·tone (hstn)
n.
Any of several small simple proteins that are most commonly found in association with the DNA in chromatin and contain a high proportion of basic amino acids.

histone
[his′tōn]
Etymology: Gk, histos, tissue
any of a group of strongly basic, low-molecular weight proteins that are soluble in water and insoluble in dilute ammonia and combine with DNA to form nucleoproteins. They are found in the nucleus of eukaryotic cells, where they form a complex with DNA in the chromatin and function in regulating gene activity. See also nucleosome.

histone [his´tōn]
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as nucleic acids or the globin of hemoglobin.

histone
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as in DNA where they have a structural and functional role.

histone acetylase, histone deacylase
enzymes responsible for the reversible acylation of four lysine residues near the N-terminus of histone H4.


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Some modifications on histones, like this acetylation on histone H4 lysine 16, are persistent and are maintained through generations of cell divisions.
Scientists have identified enzymes that acetylate, deacetylate, phosphorylate, dephosphorylate, and methylate histones.
Histone deacetylases (HDACs) are enzymes that remove acetyl groups from lysines of histones and other non-histone proteins, and figure prominently in chromatin modifications that lead to changes in gene expression.
 
 
 
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