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histone
(redirected from Histone modification)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
histone /his·tone/ (his´tōn) a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, e.g., the protein combined with nucleic acid or the globin of hemoglobin.
his·tone (hstn)
n.
Any of several small simple proteins that are most commonly found in association with the DNA in chromatin and contain a high proportion of basic amino acids.

histone
[his′tōn]
Etymology: Gk, histos, tissue
any of a group of strongly basic, low-molecular weight proteins that are soluble in water and insoluble in dilute ammonia and combine with DNA to form nucleoproteins. They are found in the nucleus of eukaryotic cells, where they form a complex with DNA in the chromatin and function in regulating gene activity. See also nucleosome.

histone [his´tōn]
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as nucleic acids or the globin of hemoglobin.

histone
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as in DNA where they have a structural and functional role.

histone acetylase, histone deacylase
enzymes responsible for the reversible acylation of four lysine residues near the N-terminus of histone H4.


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Scientists in medicine and nutrition from the US and UK explore the interrelationships between nutrition and epigenetic phenomena, including DNA methylation, histone modifications, and chromatin remodeling; the role of epigenetics in embryonic development, aging, inflammation, and the development of cancer; and how nutrients affect and modulate these physiologic and pathologic processes.
Berger, (2006) Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.
In earlier studies, scientists had found that histone modifications appear to silence individual genes in the DNA that coils around affected histones.
 
 
 
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