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high-dose chemotherapy

   Also found in: Acronyms 0.02 sec.
high-dose chemotherapy
Oncology The administration of chemotherapeutics in excess of BM toxicity; given the risk of aplastic anemia, HDC requires autologous BMT and use of 'rescue' factors such as G-CSF, GM-CSF, and erythropoietin. See Bone marrow transplantation.


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After admission, she received high-dose chemotherapy for 2 days before undergoing autologous peripheral stem cell transplantation on the third day.
The incidence of this disease is increasing in the entire scope of patients with severe granulocytopenia, including hematologic malignancies, solid tumors receiving high-dose chemotherapy, and profound neutropenic sites such as acquired immunodeficiency syndrome.
Rothschild said the company does not make revenue projections, but she conceded the drug won't likely match sales of Neupogen, given that there are relatively few high-dose chemotherapy patients.
 
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