genetic disorder

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genetic disorder

A pathological condition caused by an absent or defective gene or by a chromosomal aberration. Also called hereditary disease.

genetic disorder

ge·net·ic dis·or·der

(jĕ-net'ik dis-ōr'dĕr)
A widely used but nonetheless imprecise term that denotes a condition or illness related to biologic inheritance.

Patient discussion about genetic disorder

Q. what makes Arthritis a genetic disease?

A. First of all, the term arthritis is a bit inaccurate: Arthritis denotes an inflammation of joints. There are many kinds of arthritis that may result from different causes, and therefore, are different diseases: septic arthritis (inflammation due to infection of joint) has much less genetic background than ankylosing spondylitis (an arthritis of the lower back joints that occurs almost exclusively in people with certain genetic background).

The arthritis with the genetic background are usually the autoimmune ones: Due to genetic determinants, the immune system of some people is programmed to recognize the various parts of the joints (and other organs as well) as foreign (i.e. like bacteria) and thus launches an attack on them. In normal immune system, that doesn't happen.

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Q. Is bipolar disease a hereditary problem? My only son is in his teens that is the age to enjoy life, but he cannot enjoy his life with his friends because we found that he is suffering from a bipolar condition. I feel so sad for him and though my care-free days have gone, I often think about how much fun I had at his age. I too suffered from a bipolar disorder and my mom too. Is bipolar disease a hereditary problem? I want him to help to enjoy his life.

A. I agree with you. No one should suffer because of hereditary problems. This is the same situation here as genes are passed from generation to generation. This information is inconclusive because many who may have had bipolar disorders did not have it checked out. Who is to say, how many people 50 years ago had it but dismissed it as being moody, or ill tempered. Doctors were not aware about this problem years ago. Some time back, someone who showed signs of a mental disorder was straight away shoved into a mental hospital and left to suffer. Besides they are often treated with electric shock therapy eventually getting out of control. Testing is still in progress to find out if genetics play a role but these theories may take several more years before they can have a better understanding.

Q. Is FMS heredetery? My mother was diagnosed with FMS and I would like to know what are the chances I’ll have it too.

A. Hereditary is not the right term. It’s not a genetic disease but The cause of fibromyalgia remains elusive. However, recent studies show that genetic factors can predispose individuals to a genetic susceptibility to fibromyalgia.

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References in periodicals archive ?
In this report, we present the natural history of the Acadian Usher syndrome population and review the efforts our laboratories have undertaken to discover the mutation that causes this heritable disease.
We believe that it will continue to be a highly useful research tool for discovery of mutations linked to heritable disease and cancer.
It opened an era of discovery in platelet and vascular biology, heritable diseases and their management, and drug development and therapies.
The Human Genome Project, the Human Genome Diversity Project, and the practice of genetic counseling for heritable diseases all have highlighted numerous medicolegal concerns.
Good laboratory practices for molecular genetic testing for heritable diseases and conditions.
Knowledge of basic brain embryology provides the foundation for making diagnoses of brain malformations, heritable diseases, congenital neoplasms and even disorders of postnatal development.
Effective gene therapy is clearly the best way to treat heritable diseases.
The first section introduces the basics of molecular biology that are required for an understanding of molecular diagnostics; section 2 describes the various techniques available and in current use; and section 3 discusses the practical applications of molecular diagnostic methods in the context of specific disease categories, such as heritable diseases, cancer, and infectious diseases.
proof-of-the-principle studies clearly suggest that cell-based therapies hold promise for treatment of these currently intractable, heritable diseases," said Dr.
This panel, known as the Quebec Linkage Disequilibrium Map (QLDM), is suitable for highly cost-effective genome-wide scans in heritable diseases to discover the common causative genes in these diseases.
The yeast genome project is important because nearly half of the proteins known to be defective in human heritable diseases show some sequence similarity to yeast protein.
Paulson, and colleagues at the University of Iowa report results that will faciliate development of siRNA therapies for heritable diseases such as Machado-Joseph disease (MJD) and other dementias in which defective proteins clump together and impair brain and nervous system function.