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hereditary hemochromatosis

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hereditary hemochromatosis,
an autosomal-recessive disorder of metabolism that involves the deposition of iron-containing pigments in the tissues. Iron accumulation is lifelong, with symptoms that include joint or abdominal pain, weakness, and fatigue appearing usually in the fifth or sixth decades of life. If untreated, the disorder may lead to bronzing of the skin, arthritis, diabetes, cirrhosis, or heart disease. It typically affects men more often than women. See also hemochromatosis.


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The common causes of Cirrhosis are hepatitis C, chronic hepatitis B; Wilson"s disease, autoimmune hepatitis, hereditary hemochromatosis, alcoholism etc.
3,17-21) The majority of human patients with hereditary hemochromatosis carry a unique missense mutation (C282Y) that alters a major histocompatability--complex class l-like protein designated HFE.
 
 
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