heparin-induced thrombocytopenia (redirected from Heparin-induced thrombopenia)

heparin-induced thrombocytopenia

Acquired thrombocytopenia affecting some heparin-treated Pts–HTPs, defined as a ↓ platelet count during or shortly after heparin exposure; HIT is a markedly prothrombotic disorder seen in Pts who are at a high baseline risk for venous thrombosis DiffDx Antiphospholipid antibody syndrome, DIC, Trousseau syndrome–migratory thrombophlebitis & malignancy, TTP/HUS, thrombocytopenia and 'showers' of microthrombi Clinical HIT occurs 6-10 days after heparin exposure Diagnosis Aggregation studies using platelets from Pts known to be sensitive to antibody; quantification of serotonin release from platelets radiolabeled with serotonin in assay using Pt serum