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heparin-induced thrombocytopenia

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heparin-induced thrombocytopenia
Acquired thrombocytopenia affecting some heparin-treated Pts–HTPs, defined as a ↓ platelet count during or shortly after heparin exposure; HIT is a markedly prothrombotic disorder seen in Pts who are at a high baseline risk for venous thrombosis DiffDx Antiphospholipid antibody syndrome, DIC, Trousseau syndrome–migratory thrombophlebitis & malignancy, TTP/HUS, thrombocytopenia and 'showers' of microthrombi Clinical HIT occurs 6-10 days after heparin exposure Diagnosis Aggregation studies using platelets from Pts known to be sensitive to antibody; quantification of serotonin release from platelets radiolabeled with serotonin in assay using Pt serum


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Testing for Heparin-Induced Thrombocytopenia (HIT) is now available from a national reference laboratory specializing in pediatric testing.
3] or if recurrent thrombosis develops (see Heparin-induced thrombocytopenia and Heparin-induced Thrombocytopenia and Thrombosis), the heparin product should be discontinued and, if necessary, an alternative anticoagulant administered.
The final chapter is dedicated to examination of the complication of heparin-induced thrombocytopenia.
 
 
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Heparinase Degraded Heparin Fragments
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heparinize
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Heparinized Complete Peripheral Blood
heparinized lock system
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heparinizing
heparitin sulfate
heparology
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