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Helicobacter pylori |
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Helicobacter pylori A gramnegative rod-shaped bacterium that lives in the tissues of the stomach and causes inflammation of the stomach lining. Mentioned in: Indigestion, Ulcers (Digestive) Helicobacter pylori, a species of spiral or straight gram-negative bacteria with multiple sheathed flagella found in the gastric mucosa of humans and other animals and associated with gastric and peptic ulcers as well as gastric cancers. Formerly called Campylobacter pylori. Helicobacter pylori (he·li·kō·bakˑ·ter pī·lōˑ·rē), Heimlich sign, n.pr a universal distress signal that a person is choking and unable to speak, made by grasping the throat with a thumb and index finger, thereby attracting the attention of others nearby. Helicobacter pylori n a gram-negative, spiral-shaped bacteria that is active as a human gastric pathogen. It is associated with lesions or gastritis or peptic ulcers. See also ulcer, peptic. Helicobacter pylori Campylobacter pylori GI disease A curved gram-negative microaerophilic bacillus which causes most cases of gastritis; it is present in 10-50% of healthy young persons and up to 60% of those ≥ age 60 Epidemiology
H pylori may be spread by houseflies–hand washing may ↓ transmission, by intrafamilial contact, or domestic cats Note: 90% of Pts with intestinal-type gastric CA have been infected by H pylori, which may be a co-factor for
gastric CA, acting either to stimulate production of cellular mutagens or induce ↑ proliferation after cell damage; it has been implicated in antibiotic-responsive duodenal ulcers, and linked to other gastric lesions, benign and malignant
Diagnosis Gastric Bx with special–eg, Diff-Quik stain, serologic tests–90-95% accuracy, urea breath test Disease course H pylori infection → chronic superficial gastritis, peptic ulcer disease, lymphoproliferative disease,
± → gastric lymphoma, chronic atrophic gastritis, ± → gastric adenoCA Management Proton-pump inhibitors–eg, omeprazole, lansoprazole, esomeprazole; antibiotics–amoxicillin, clarithromycin, metronidazole;
ranitidine; bismuth subcitrate. See Duodenal ulcer, Gastric lymphoma, Urea breath test. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The mode of transmission of Helicobacter pylori infection is poorly characterized. Currently indicated for the treatments of gastric ulcer, duodenal ulcer as well as an adjunct to Helicobacter pylori eradication, Takepron is now available for the treatment of non-erosive gastroesophageal reflux disease. Red meat may increase the risk of stomach cancer in people who have Helicobacter pylori infections, according to the European Prospective Investigation into Cancer and Nutrition, which tracks more than 500,000 men and women in ten European countries. |
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