helicase


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helicase

(hel-ĭ-kāz),
A general term describing enzymes capable of unwinding the DNA double helix beginning at the replication fork.
See also: Werner syndrome.

helicase

An enzyme that breaks the hydrogen bonds between the BASE PAIRS in DNA thus separating the two strands of the double helix in the process of replication. Helicase works in conjunction with single-strand binding proteins that attach to the outer side of each single strand preventing the two from rebonding so that two rows of free-ended bases are left as templates on which new complementary strands can be formed.

helicase

an ENZYME that can unwind a NUCLEIC ACID DUPLEX. It disrupts the hydrogen bonds and requires ATP to function.

helicase

an enzyme involved in DNA replication, responsible for unwinding the double helix.
References in periodicals archive ?
5] Human genes: BRCA1, breast cancer 1, early onset; BRCA2, breast cancer 2, early onset; APOE, apolipoprotein E; ERBB2 (formerly HER2/Neu), v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; CHD7, chromodomain helicase DNA binding protein 7.
The uvrD gene encodes a type 11 DNA helicase involved in DNA replication and repair.
Among the newly identified mutations was one in an RNA helicase gene, DDX3X, which Cho said is the second-most common mutation in medulloblastoma tumors.
The 5'-proximal ORF encodes for the non-structural proteins, helicase, protease, and RNA-dependent RNA polymerase (RdRp) and the 3'-proximal ORF for the structural (or capsid) proteins.
SAN DIEGO - Helicase primase inhibitors, such as the investigational drug ASP2151, could offer an alternative therapeutic approach in the treatment genital herpes.
CHARGE syndrome is an autosomal dominant genetic disorder that is typically caused by mutations in the chromodomain helicase DNA binding protein-7 (CHD7) gene.
First Place ($1,500 award): Utility of Lymphoid-Specific Helicase in Differentiating Follicular Hyperplasia From Follicular Lymphoma.
DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs.
The sequences of outer and inner primers used were from NS3 helicase region of the HGV genome.
1| chromodomain helicase DNA binding protein 1 (Gallus gallus) RUCV185 gb|ABW97741.