helicase


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helicase

(hel-ĭ-kāz),
A general term describing enzymes capable of unwinding the DNA double helix beginning at the replication fork.
See also: Werner syndrome.

helicase

An enzyme that breaks the hydrogen bonds between the BASE PAIRS in DNA thus separating the two strands of the double helix in the process of replication. Helicase works in conjunction with single-strand binding proteins that attach to the outer side of each single strand preventing the two from rebonding so that two rows of free-ended bases are left as templates on which new complementary strands can be formed.

helicase

an ENZYME that can unwind a NUCLEIC ACID DUPLEX. It disrupts the hydrogen bonds and requires ATP to function.

helicase

an enzyme involved in DNA replication, responsible for unwinding the double helix.
References in periodicals archive ?
Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.
In the pi-body, the complex interacts with mouse vasa homolog Mvh RNA helicase (DDX4).
A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.
TLRs, NLRs, and helicase receptors) found on innate immune cells play a pivotal role particularly in the defense against viral infections.
RNA helicase p68 was first identified as 65 kDa protein (p65) by methylene blue-mediated cross-linking (MB-cross- linked) interacting with the U1snRNP when it was bound at5`ss of intron in spliceosome formation by Liu et al.
Genome-wide analysis of helicase gene family from rice and Arabidopsis: a comparison with yeast and human.
This study was based on Chromo Helicase DNA-binding genes (CHDW/CHDZ genes) (Ellegren and Sheldon, 1997) due to their proven usage in almost all bird species, with the exception of ratites (Griffiths et al.
Among the topics are dormant replication origins, break-induced DNA replication, the mini-chromosome maintenance replicative helicase, the spatial and temporal organization of DNA replication in bacteria and eukarya, DNA replication timing, replication-fork dynamics, sister chromatid cohesion, translesion DNA polymerases, rescuing stalled or damaged replication forks, genome instability in cancer, regulating DNA replication in plants, endoreplication, the archaeology of eukaryotic DNA replication, human mitochondrial DNA replication, whether human papillomavirus infections are warts or cancer, and adenovirus DNA replication.
The Role of a UvrD Helicase and the SOS Response in Pseudomonas syringae pv.
1998) which is required for ubiquitin ligase activity, the MRE11/RAD50/NBS1 (M/R/N) recombination repair complex, a putative DNA helicase BRCA1-associated C-terminal Helicase (BACH1) (Cantor et al.
For example, a question that calls for a description of DNA replication should have key words in the response that include semiconservative mechanism, origin of replication, leading strand, lagging strand, and relevant enzymes such as helicase and DNA polymerase; these are some of the terms I would check for in the student's answer.
Among the newly identified mutations was one in an RNA helicase gene, DDX3X, which Cho said is the second-most common mutation in medulloblastoma tumors.