HSPD1

(redirected from Heat Shock Protein 60)
Also found in: Acronyms.

HSPD1

A gene on chromosome 2q33.1 that encodes a mitochondrial protein of the chaperonin family, which may function as a signalling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in mitochondria. HSPD1 is adjacent to a related gene; the region between the two acts as a bidirectional promoter.

Molecular pathology
HSPD1 mutations cause autosomal recessive spastic paraplegia 13.
References in periodicals archive ?
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
Plasma antibodies to heat shock protein 60 and heat shock protein 70 are associated with increased risk of electrocardiograph abnormalities in automobile workers exposed to noise.
Circulating heat shock protein 60 is associated with early cardiovascular disease.
Immunology of atherosclerosis: demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions.
Increased titres of anti-human heat shock protein 60 predict an adverse one year prognosis in patients with acute cardiac chest pain.
Circulating human heat shock protein 60 in the plasma of Br civil servants: relationship to physiological and psychosocial stress.
Chlamydia pneumoniae in abdominal aortic aneurysms: abundance of membrane components in the absence of heat shock protein 60 and DNA.
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