For this prospective case-control study, we identified subjects with the Hb SC genotype, the presence of which had been confirmed in our hematology outpatient clinic.
We also observed that hearing loss was three times more common among the females in the Hb SC group than the males, although the difference was not statistically significant.
105 Hearing loss ([dagger]) Right ear only Left ear only Both ears * Hb SC vs.
The degree of clinical morbidity among individual adults with Hb SC disease varies.
Patients with Hb SC
disease typically have erythrocyte life spans of -29 days (5).
Whereas the more common sickling disorders (Hb SS, Hb SC, Hb SD-Punjab, Hb SE, Hb SG-Philadelphia, Hb SHope, Hb SLepore, Hb SO-Arab, and Hb S/[beta]-thal) are all clinically significant, these combinations do present different manifestations and degrees of severity (24, 25), making precise identification important.
n) Hb AS, Hb SS, Hb SC, Hb S/ [beta]-thal, Hb SE, Hb SG-Philadelphia, Hb SO-Arab, Hb SJ-Toronto, and Hb SFukuyama included.
These situations are clinically important because Hb SD-Punjab and Hb SC are both significant sickling disorders, whereas Hb SD-Iran and Hb SE-Saskatoon are clinically benign (24, 25).
When no Hb A is present in the sample, as for example in the variant Hb SC
, an "abnormal separation" message is printed and no result displayed (Fig.
Subjects included individuals with Hb AA, Hb AS, Hb SC
, and Hb SS genotypes; the presence of Hb S in the blood samples did not affect the [Hb] measurements (data not shown).
In addition, these assays create an increased risk for reporting misleading HbA1c results for patients harboring homozygous Hb S, Hb SC, or Hb S-b-thalassemia, where red blood cell life span is decreased.
Average lifespan of RBCs for normal and variant hemoglobins Hemoglobin (Hb) Average RBC Span (days) Hb AA 120 Hb AS 93 (12) Hb AC 87 (13) Hb SS 17 (12) Hb SC 28 (13) Hb CC 29 (12) Hb S-Beta--thal 75 (12) Table 3.