Not long ago, the microbiologist Leonard Hayflick
was asked what had changed since he began his career 55 years ago.
Past recipients include Professor Leonard Hayflick
, who discovered the Hayflick
limit to cell division, and Emeritus Professor of the Newcastle University Institute for Ageing, Professor Tom Kirkwood CBE who proposed the evolutionary concept of disposable soma.
But it focuses primarily on three characters: Leonard Hayflick
, a brilliant but stubborn cell culturist; Stanley Plotkin, a physician bent on discovering a rubella vaccine in time to stave off an impending epidemic; and Hilary Koprowski, their colorful, visionary boss and head of the Wistar Institute in Philadelphia.
Vaccination is a particularly important issue to think about now, given the rise of an anti-vaccine movement that has the potential to reverse the health gains achieved through one of the most powerful interventions in medical history," said study co-author Leonard Hayflick
, PhD, who developed WI-38, in a news release.
The history of senescence starts with the discovery of the Hayflick
limit in 1961.
Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick
For the karyotyping process, the cells (subcultured at a 1:3 dilution, both early passages and after reaching the Hayflick
limit) were subjected to a 4-hour demecolcemid (Sigma cat.
Telomere length and its accelerated shortening due to reparative replication is the basis of this theory, which was first described by Hayflick
in 1965, in response to the observation of a decline in functionality of cell cultures (fibroblasts) which had undergone numerous cell divisions .
Biologists Leonard Hayflick
and Colin Blakemore appearas skeptical counterpoints.
Replicative senescence of T cells: does the Hayflick
Limit lead to immune exhaustion?
Rose (1998), and outspoken opponents, like, for example, Leonard Hayflick
The theory of cellular aging by Hayflick
(USA, 1965)  and the materially complementing its theory by Olovnikov (the uSsr, 1971) allowed understanding the causes of apoptosis and accumulation of "old" inefficiently functioning cells .