infection may induce hemorrhagic fever with renal syndrome (HFRS), presenting with fever and acute kidney injury.
The last possible limitation is that serum samples from PUUV-infected patients cross-react strongly with Sin Nombre virus and weakly with Hantaan virus
, Seoul virus, and Dobrava virus (36,37).
Epidemic hemorrhagic fever is caused by the Hantaan virus
and has an incubation period of a few days to four weeks, according to Hong Kong's Health Department.
In China, HFRS is predominantly caused by Hantaan virus
and Seoul virus, which have Apodemus agrarius and Rattus norvegicus, respectively, as their rodent hosts (Yan et al.
There are 4 known rodent-borne hantaviruses in the ROK: Hantaan virus
(Korean Hemorrhagic Fever (KHF)), Seoul virus, Soochong virus, and Muju virus.
The Old World hantaviruses Dobrava (DOBV), Puumala (PUUV), and Tula (TULV) cause HFRS in Europe (6-8), whereas Hantaan virus
(HNTV) and Seoul virus (SEOV) are the most prominent HFRS pathogens in Asia (9).
KHF is a widespread and often fatal illness caused by a rodent-borne species of Hantavirus known clinically as Hantaan virus
The type of HFRS, which was diagnosed in Yugoslavia, caused by the Hantaan virus
, is often fatal.
However, researchers have known for a few years that the Hantaan virus
causing it is common in U.
In China, HFRS is caused mainly by 2 serotypes of hantavirus: Hantaan virus
(HTNV) and Seoul virus (SEOV) (4).
(HTNV) 76-118 is the prototype strain of the HV genus and the hantaan serotype (1).
In Asia, Hantaan virus
and Seoul virus cause most HFRS cases.