Hamburger’s law

Hamburger’s law

The principle that chloride concentrates in erythrocytes while phosphate and albumin diffuse from erythrocytes in low pH, and, with a high serum pH, the opposite occurs. The law is no longer eponymously dignified.

While this obsolete law is generally valid, intact cell membranes have a low permeability for high molecular weight molecules (albumin = 69 kD), nor does it address the concept of gated membrane channels. The law is attributed to Hartog Jakob Hamburger (1859–1925), a Dutch physiologist.