hemorrhagic disease of the newborn

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hem·or·rhag·ic dis·ease of the new·born

a syndrome characterized by spontaneous internal or external bleeding accompanied by hypoprothrombinemia, slightly decreased platelets, and markedly elevated bleeding and clotting times, usually occurring between the third and sixth days of life; effectively treated with vitamin K.

hemorrhagic disease of the newborn

A neonatal condition caused by vitamin K deficiency, the combined result of a lack of unbound maternal vitamin K, immaturity of the fetal liver and lack of vitamin K-producing bacteria in the infant colon Clinical Abrupt early postpartum onset with spontaneous nasogastric or intracranial hemorrhage, affecting up to 1/1000 neonates and carrying a 5-30% mortality, if untreated; the condition may be more common in breast-fed infants and is more severe and of earlier onset in infants of mothers receiving anticonvulsives–antagonistic to warfarin during pregnancy Lab ↑ PT due to extrinsic factor depletion, ↑ clotting time, ↓ liver-dependent coagulation factors. Cf Hemolytic disease of the newborn.

hem·or·rhag·ic dis·ease of the new·born

(HDN) (hem'ŏr-aj'ik di-zēz' nū'bōrn)
A syndrome characterized by spontaneous internal or external bleeding accompanied by hypoprothrombinemia, slightly decreased platelet counts, and markedly elevated bleeding and clotting times, usually occurring between the third and sixth days of life and effectively treated with vitamin K.
Synonym(s): haemorrhagic disease of the newborn.

hemorrhagic

pertaining to or characterized by hemorrhage.

hemorrhagic bowel disease of swine
see proliferative hemorrhagic enteropathy.
canine hemorrhagic fever
see canine ehrlichiosis.
hemorrhagic diathesis
a tendency to bleed due to any one or a combination of clotting defects. Occurs, for example, in diseases of liver in which there may be defects in the prothrombin complex, or in fibrinogen or thromboplastin availability. See hemophilia, purpura hemorrhagica, disseminated intravascular coagulation.
hemorrhagic disease
an undifferentiated disease manifested by unprovoked hemorrhage and caused by any one of a number of factors. See also hemophilia, epizootic hemorrhagic disease of deer, warfarin, canine ehrlichiosis, hemorrhagic syndrome (below).
hemorrhagic disease of the newborn
see neonatal hemorrhagic disease (below).
hemorrhagic enteritis
an acute, highly fatal disease of turkeys over 4 weeks of age characterized by bloody droppings, a short course and a high prevalence and caused by an adenovirus.
hemorrhagic enterotoxemia
profound toxemia accompanied by hemorrhagic enteritis. It is caused by Clostridium perfringens types A, B, C and E.
hemorrhagic foal enteritis
see antibiotic-associated colitis.
neonatal hemorrhagic disease
hemorrhagic disease of the newborn; may be due to maternal isoimmunization, e.g. in pigs. See also umbilical hemorrhage.
hemorrhagic septicemia
a septicemic pasteurellosis of cattle and other ruminants, rarely of pigs and horses. It is caused by Pasteurella multocida type 1 (or B) rarely D or E, and characterized by a sudden onset of high fever, dyspnea, salivation, hot painful subcutaneous swellings and submucosal petechiae and death in about 24 hours. Called also septicemic pasteurellosis, el guedda.
Occurs also in finfish, caused by opportunist bacteria including Aeromonas, Pseudomonas spp.
hemorrhagic shock
see shock.
hemorrhagic syndrome
a widespread disease of domestic fowl causing significant losses due to death in birds about 5 to 9 weeks of age. The cause may be multifactorial but viruses are suspected to play an important role. Characterized by clinical anemia, leukopenia, anemia and hemorrhages in all tissues.
References in periodicals archive ?
Haemorrhagic disease of the newborn in the British Isles: two year prospective study.
Haemorrhagic Disease of the Newborn (HDN) is a bleeding disorder in otherwise healthy infants.