hemoglobin C

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he·mo·glo·bin C

[MIM*141900.0038]
an abnormal Hb with substitution of lysyl residue for glutamyl at the 6th position of the β chain, of formula α22Aβ26Glu→Lys, this type reduces the normal plasticity of erythrocytes. Heterozygotes: Hb C trait, about 28-44% of total Hb is Hb C, no anemia. Homozygotes: nearly all Hb is Hb C, moderate normocytic hemolytic anemia. Patients heterozygous for both Hb C and Hb S (Hb SC disease) and for Hb C and thalassemia are known, and have atypical hemolytic anemias; sickling is enhanced in Hb SC disease.

hemoglobin C (Hb C)

an autosomal recessive qualitative hemoglobinopathy in which lysine is substituted for glutamic acid at position 6 of the beta globin chain. Deoxygenated red cells crystallize to form a hexagonal "bar of gold" crystal that slows their passage. Target cells are prominent. Hemoglobin C migrates slowly in hemoglobin electrophoresis, a trait used to identify its presence.

he·mo·glo·bin C

(Hb C) (hē'mō-glō'bin)
An abnormal hemoglobin that affects the physical properties of erythrocytes, causing hemolytic anemia; often found in patients also having sickle cell disease or thalassemia.
Synonym(s): haemoglobin C.

hemoglobin C

A hemoglobin molecule in which lysine is substituted for glutamic acid at the sixth position of the beta chain. This substitution decreases the solubility of the hemoglobin molecule and increases the rigidity of the red blood cell membrane.
See also: hemoglobin