haemochromatosis


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haemochromatosis

he·mo·chro·ma·to·sis

(hē'mō-krō-mă-tō'sis)
A disorder of iron metabolism characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissue, particularly in the liver, pancreas, and skin; cirrhosis, diabetes mellitus (bronze diabetes), bronze pigmentation of the skin, and, eventually heart failure may occur; also can result from administration of large amounts of iron orally, by injection, or in forms of blood transfusion therapy.
Synonym(s): haemochromatosis.
[hemo- + G. chrōma, color, + -osis, condition]

haemochromatosis

A rare genetic disease featuring abnormal absorption and retention of iron. Total body iron may rise from the normal 4 or 5 g to as much as 60 g and the stored iron may cause CIRRHOSIS of the liver, DIABETES, IMPOTENCE, HEART FAILURE and bronzing of the skin. Treatment is by regular weekly bleeding until the levels of serum iron reach normal. The drug desferrioxamine is also useful.

he·mo·chro·ma·to·sis

(hē'mō-krō-mă-tō'sis) [MIM*235200]
Disorder of iron metabolism characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissue, particularly in the liver, pancreas, and skin; cirrhosis, diabetes (bronze diabetes), bronze pigmentation of the skin, and, eventually heart failure may occur; can also result from administration of large amounts of iron orally, by injection, or in forms of blood transfusion therapy.
Synonym(s): haemochromatosis.
[hemo- + G. chrōma, color, + -osis, condition]
References in periodicals archive ?
As a result it is important for all medical practitioners to be aware of haemochromatosis and its risk factors and to start treatment as early as possible.
Kaltwasser and colleagues (1998) conducted a more recent non randomised controlled trial involving 18 subjects, all of whom were diagnosed with hereditary haemochromatosis.
Prevalence of the C282Y and H63D mutations in the HFE gene in patients with hereditary haemochromatosis and in control subjects from Northern Germany.
He had, in fact, an inherited blood condition called haemochromatosis.
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.
It is predominantly found in men 50-60 years of age, and is most commonly due to cirrhosis secondary to alcoholism, viral Hepatitis B or C, haemochromatosis, or autoimmune diseases.
The origin and spread of the HFE-C282Y haemochromatosis mutation.
Hethought I might be suffering from haemochromatosis, which is an excess of iron in the blood.
Chantelle has haemochromatosis, causing the body to absorb an excessive amount of iron from the diet.
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.
Shocking new research by medical students at Dublin's Trinity College shows just 30 per cent of us have even heard of haemochromatosis, the potentially fatal birth-defect we are proven to be most likely to have.
Then in 1935, Sheldon described the hereditary nature of the disease in his text Haemochromatosis.