The use of these names can cause some confusion, because the name HTLV-III
was one of the names of HIV in early AIDS literature, but has since fallen out of use (11).
14) claimed to have isolated HTLV-III
from 26 of 72 AIDS patients, 18 of 21 individuals with pre-AIDS, 3 of 4 healthy mothers of children with AIDS, and 1 of 22 "normal male homosexual subjects.
Isolation of HTLV-III
from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome.
report that they had inadvertently used a picture of a virus grown from material provided by Montagnier's laboratory -- thus, LAV-I -- as an illustration in their initial article describing the HTLV-III
virus (SN: 4/28/84, p.
While the Frederick work firms up the virus's position in the lentivirus family, it won't help in naming the virus, which is variously called HTLV-III
, LAV (for lymphadenopathy-AIDS virus) or ARV (for AIDS-related virus).
In culture, the HTLV-III
virus doesn't change much, so many of the genetic changes in the virus probably occur when the viral DNA is transcribed into DNA in the body, says Gallo.
since central nervous system cells are not affected
Recent studies throughout the United States have shown that patients and their specimens do not transmit HTLV-III
to health care workers.
The scientists looked for the presence of antibodies to HTLV-III
, a putative cause of AIDS, and found it in 50 to 75 samples checked, suggesting, they say, "that the virus detected may have been a predecessor of HTLV-III
itself but existing in a population acclimated to its presence.
To date, the Food and Drug Administration has licensed five manufacturers to market kits detecting antibodies to HTLV-III
When Robert Gallo nine months ago announced HTLV-III
as the U.
Even before the ELISA test for antibodies to HTLV-III
, the incidence of transfusion-associated AIDS reportedly fell from 1 in 100,000 to 1 in 1,000,000.