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HTLV-I

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HTLV-I
n.
Human T-cell lymphotropic virus type I; a retrovirus that causes diseases similar to multiple sclerosis.

HTLV-I Virology A retrovirus that immortalizes T cells; it is associated with 1. Adult T-cell lymphoma/leukemia in endemic regions of southern Japan–where up to 40% of leukemic Pts are HTLV-I-positive, and the Caribbean 2. Chronic progressive myelopathy–tropical spastic paralysis, a condition endemic to the Caribbean, tropical Africa, and South America and 3. HTLV-I-associated neuropathy; HTLV-I, like HIV-1, is blood-borne Carrier prevalence–US, Europe up to 0.10%; 1% of HTLV-I-infected subjects develop clinical disease, which may reflect host susceptibility and variant viral strains


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Viruses detected in HTLV-I associated myelopathy and adult T-cell leukaemia are identical on DNA blotting.
Others are human papillomavirus (HPV), a cause of cervical cancer; HTLV-I, which can cause a rare cancer or a paralytic illness; mycoplasma, which causes urethritis; mobiluncus, which causes vaginosis; and human herpes virus 8, which causes Kaposi's sarcoma and lymphoma.
The team's technique rapidly and unambiguously discriminates between HTLV-I and HTLV-II, Chen says.
 
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