HSPB1

HSPB1

A gene on chromosome 7q11.23 that encodes a member of the (small) heat shock protein 20 family which is induced by environmental stress. HSPB1 plays a role in stress resistance and actin organisation; it translocates from the cytoplasm to the nucleus in response to stress. It associates with alpha- and beta-tubulin, microtubules and CRYAB, and interacts with HSPB8 and HSPBAP1.

Molecular pathology
Defects of HSPB1 cause Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy 2B.
References in periodicals archive ?
All these patients were out of 315 unrelated Chinese CMT families and genetically undiagnosed after exclusion of pathogenic variants of PMP22, MFN2, MPZ, GJB1, GDAP1, HSPB1, HSPB8, EGR2, NEFL, and RAB7.
These patients were negative for pathogenic variants of PMP22, MFN2, MPZ, GJB1, GDAP1, HSPB1, HSPB8, EGR2, NEFL , and RAB7 .
33) Some of the proteins in these 2 categories are implicated in several signaling pathways, for example HMGB (p53 pathway) and HSPB1 (p38 MAPK and VEGF signaling pathway).
Spot Accession number number Protein name M17 K22E Keratin, type II cytoskeletal 2 epidermal M18 Q6NTA2 HNRNPL protein M19 Q32Q12 Nucleoside diphosphate kinase M20 ALDOA Fructose-bisphosphate aldolase A M21 PEBP1 Phosphatidylethanolamine-binding protein 1 M22 PGAM1 Phosphoglycerate mutase 1 N13 GMFB Glia maturation factor beta N14 HSPB1 Heat shock protein beta-1 N15 TP1S Triosephosphate isomerase M23 PGAM1 Phosphoglycerate mutase 1 M24 ENOA Alpha-enolase Spot Theoretical Theoretical Number of number Gene name Mr pl peptide Score M17 KRT2 65,678.
HSPB1 counteracts apoptosis, protects cytoskeleton and after phophorylation is supposed to prevent relaxation of smooth muscles.
Targeted next-generation sequencing reveals further genetic heterogeneity in axonal Charcot-Marie-Tooth neuropathy and a mutation in HSPB1.
HSPB1 expression in both mRNA and protein was shown to be negatively related to intramuscular fat content and was regulated by FAS and angiotensinogen.
HSPB1 was up regulated in LD and DP depots during myogenic differentiation, whereas TCP-1 was identified in ST depot and its protein expressions were up regulated.
The HSPB1 and TCP-1 are chaperone proteins that promote cell survival during physiological stress (Sternlicht et al.
Our image analysis along with in-depth spot analysis (lower panel of Figure 4A, B and C) revealed omental depot with higher expressions of ANXA 6, HSPB1, TAGLN, ALDH1A1 and CALD 1, whereas in the subcutaneous depot, expressions of PRDX 6 and GSN were found to be high.