HOXA9

HOXA9

A gene on chromosome 7p15.2 that encodes a sequence-specific transcription factor of a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation.
 
Molecular pathology
A specific translation event, resulting in the fusion of HOXA11 and NUP98, which is associated with myeloid leukaemogenesis.
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Prognostic Significance Established Likely Potential Favorable NPM1 mutations CEBPA Unfavorable MiA-PTD mutations FLT34TD KIT WTI FLT3-TK0 Unfavorable BAALC EVII overexpression ERG HOXA9 MN1 MEISI Clinical testing Recommended Optional Investigational
Rearrangements of MLL result in the recruitment of DOT1L activity to aberrant gene locations, leading to the expression of the leukemia-causing genes HOXA9 and MEIS1.
The genes involved included HOXA9 and MN1, both previously linked to leukemia, and GATA2 and FLII, which play roles in normal development of the megakaryocytic blood cells that are targeted in AMKL.