HOXA9

HOXA9

A gene on chromosome 7p15.2 that encodes a sequence-specific transcription factor of a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation.
 
Molecular pathology
A specific translation event, resulting in the fusion of HOXA11 and NUP98, which is associated with myeloid leukaemogenesis.
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mir-196a HOXA9 Related to pediatric acute lymphoblastic leukemia and participation in myeloid differentiation mir-15 BCL2 Related to chronic lymphocytic leukemia mir-150 MYB Inhibition of leukemogenesis (*) Selected putative targets are predicted using Target scan and miRBase online websites Table 2: Expression levels of the selected miRNAs before and after in vitro culture MicroRNA Expression Expression Ratio of level in level in expressions Sample 1 Sample 2 in Sample 2 to Sample 1 mir-125a 2.
HOXA9 is a master transcription factor that controls a network of genes critical for hematopoiesis.
In addition, in vitro and in vivo functional studies showed that TET1 coregulated with MLL fusion proteins to prompt oncogenic target gene expression including HOXA9, myeloid ecotropic viral integration 1/pre-B-cell leukemia homeobox3 genes.
DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
Frequent methylation of HOXA9 gene in tumor tissues and plasma samples from human hepatocellular carcinomas," Clinical Chemistry and Laboratory Medicine, vol.
HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: array-based DNA methylation and expression profiling.
Prognostic Significance Established Likely Potential Favorable NPM1 mutations CEBPA Unfavorable MiA-PTD mutations FLT34TD KIT WTI FLT3-TK0 Unfavorable BAALC EVII overexpression ERG HOXA9 MN1 MEISI Clinical testing Recommended Optional Investigational