HOXA1

HOXA1

A gene on chromosome 7p15.3 that encodes a sequence-specific transcription factor for a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation. HOXA1 protein may be involved in correctly positioning the hindbrain segments along the anterior-posterior axis during embryonic development.
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MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene.
Six loci (DAPK, HOXA1, CRABP1, TWIST1, GRIN2B, and TIMP3) showed statistically higher methylation levels in adult samples than in pediatric samples (all values, P < .
DAPK, HOXA1, CRABP1, TW1ST1, GR1N2B, T1MP3, NEUROG1, and SMAD9 showed statistically higher methylation levels in adult samples than in pediatric samples (all values, P < .
We also noted differences in the methylation levels of individual loci between results from H pylori-negative adult samples and H pylori-negative pediatric samples: 6 loci (DAPK, HOXA1, CRABP1, TW1ST1, GR1N2B, and T1MP3) showed statistically higher methylation levels in adult samples than in pediatric samples (all values, P < .
We added 11 markers [GATA3, GATA binding protein 3; GDNF, glial cell derived neurotrophic factor; OPCML, opioid binding protein/cell adhesion molecule-like; PENK, proenkephalin; TFAP2A, transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); APP, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); CACNA1G, calcium channel, voltage-dependent, T type, alpha 1G subunit; HOXA1, homeobox A1; NEUROG1, neurogenin 1; APBA2, amyloid beta (A4) precursor protein-binding, family A, member 2; and TRRAP, transformation/transcription domain-associated protein on the basis of a study that indicated increased methylated DNA in CRC tissue (19).
MOLECULAR CLONING OF HOXA1 FROM RAT FETAL BRAIN TISSUE
The researchers focused on HOXA1 because of the high rate of autism among babies who are exposed to thalidomide early in gestation.
In the 57 subjects, autism was more pronounced in people who inherited the variant HOXA1 gene from their mothers than in those who inherited it from their fathers.
A variant of a gene known as HOXA1, which supervises fetal-brain development, may predispose people to develop autism or several related disorders, according to a report in the December TERATOLOGY.
In a DNA analysis, 22 of the 57 participants--about 40 percent--exhibited the HOXA1 variant.
Table 1: The target gene predicted for miR-4284 and miR-4484 as well as their role in cells Target genes Roles in cells miR-4284 TRAF4, BCL 10, Apoptosis, HDAC, HOXA1, differentiation, PTEN proliferation miR-4484 AATF, PTPN14, PI3K, PTEN Apoptosis