HOTAIR

HOTAIR

HOX transcript antisense RNA (non-protein coding). A gene on chromosome 12q13.13 that encodes long noncoding RNAs (ncRNAs), which have roles in gene regulation, especially in epigenetic control of chromatin.
References in periodicals archive ?
Hox transcript antisense RNA ( HOTAIR ), a long intervening ncRNA (lincRNA) transcribed from HOXC, is involved in epigenetic regulation, cooperative with polycomb repressive complex 2 and required for histone H3 lysine-27 trimethylation of the HOXD.
Interactions between HOTAIR and PRC1/PRC2 are not well characterized at the molecular level.
Bisphenol A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo.
Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma.
Por otra parte, en cancer de pulmon NSCLC se ha establecido que la sobrexpresion de los lncRNA MALAT1 y HOTAIR esta asociada con metastasis y mal pronostico, respectivamente [7] (tabla 4).
Epigenetic silencing of p21 by long non-coding RNA HOTAIR is involved in the cell cycle disorder induced by cigarette smoke extract.
Numerous IncRNAs including HOTAIR contribute to bridge the limited number of polycomb proteins and the diverse tissue-specific genome modifications.
HOTAIR is an abbreviation for long, non-coding RNA, a part of DNA in humans and other vertebrates.
HOTAIR does not produce a protein on its own but, when it is being expressed or functioning, it can suppress genes that would normally slow tumor growth or cause cancer cell death.
A study reported last year in Nature, from Stanford University genomicist Howard Chang and his colleagues, showed that HOTAIR works at 854 different job sites.