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HLA-B27 |
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HLA-B27 An antigen or protein marker on cells that may indicate ankylosing spondylitis. Mentioned in: Ankylosing Spondylitis human lymphocyte antigen B27 (HLA-B27) test, a blood test done as part of paternity investigations, to indicate tissue compatibility with tissue transplantation, and to assist in the diagnosis of Reiter's syndrome and other conditions. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The pathogenesis of Reiter syndrome may involve molecular mimicry between microbial fragments in synovial fluid and the HLA-B27 molecule; however, it is unknown whether microbial fragments of Cyclospora could be found in synovial fluid, and in this case the patient was HLA-B27 negative (6). Taurog and his colleagues went on to show that when they raised HLA-B27 rats in a sterile environment, the animals failed to develop arthritis or colitis. The HLA-B27 transgenic rat contains a human gene that predisposes the animal to arthritis. |
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