HLA match

HLA match

Immunology The number of HLA antigens at the HLA-A, B, and DR loci of donor and recipient that match, from a maximum of 6 to minimum of 0. Cf HLA mismatch.
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k)] can be derivate with respect to k donors in order to estimate the number of additional donors required to increase by 1% the expectative of finding a donor with complete or partial HLA match for a q recipient in the waiting list.
This technique allows couples to se in vitro fertilisation (IVF) with pre-implantation genetic diagnosis to identify embryos that are an HLA match and only use those embryos to establish pregnancy," he added.
8) The embryo created would be a definite HLA match, and, upon birth, could begin to serve as a hematopoietic stem cell transplant ("HSCT") donor for a compatible person in need, such as a sick sibling.
This demonstrates the continued risk of allogeneic stem cell transplantation, as the patient in question was a 10 out of 10 HLA match, was on appropriate immunosuppressive therapies to prevent such a reaction and still developed significant GvHD complications in less than one month.
If the blood is an HLA match for the sick child, those cells could potentially be used in the child's treatment.
Once we found an HLA match, we implanted the embryo into the mother's uterus.
Umbilical cord blood, the other alternative source of stem cells, is useful for children and for small adults (under 50 kg) and furthermore requires a less stringent HLA match.
And, there has always been a considerable chance that the recipient's body will reject the transplanted cells (graft-versus-host disease), even from siblings, who provide the best chance for perfect HLA match.
There is a 25% chance of a 6/6 haplo-identical HLA match for each sibling, which is the ideal situation for a transplant.
Multiple cycles of IVF and PGD are often needed to produce an HLA match.
There are different methods for assuring a close HLA match, and they raise different issues.
Even though 66 patients received cordblood that was not a perfect HLA match, 20% of recipients in the cord blood group had severe acute GVHD.