HIV virion

HIV virion

Virology A virion with a 100 nm in diameter lipid envelope surrounding a dense cylindrical nucleoid containing core proteins, reverse transcriptase and a genome with sequence similarity to non-cell-transforming lentiviridae–eg, visna and caprine encephalitis viruses; envelope proteins gp41, gp120; nucelocapsid proteins p24, p17, p9, p7
References in periodicals archive ?
These data may suggest a possible role for antigenic stimulation directly by the HIV virion or other antigens in the pathogenesis of plasma-cell neoplasms in HIV-associated cases, and may indicate a causative role for HIV or an HIV-associated infection in MM.
The role of coinfection by HIV in the transformed cells of this case is unclear Some authors have reported increased HIV virion expression in cells infected by EBV.
Fusion of the HIV virion with the human cell is one of the earliest steps in the HIV life cycle.
PhotoImmune's photo-labeling technique results in a complete but inactivated HIV virion particle.
However, opposite data were also reported: overexpression of peroxide-scavenging enzyme, GPx1, enhances production of HIV virions, whereas treatment of such cells with buthionine sulfoximine (BSO) that inhibits glutathione biosynthesis inhibits such increase [158].
The second theory of entry postulates that HIV virions in the blood physically penetrate the BBB at the tight junctions of the basement membrane and cross freely into the CNS to infect local microglial cells that also differentiate into macrophage and, further, HIV infection and replication (Ghafouri et al.
2) HIV virions and virion-infected cells cross epithelial barriers of the genital tract within a matter of hours, remain in the submucosa for three to six days where they may infect WBCs, then rapidly disseminate via draining lymphatics and establish CD4 T-cell viral reservoirs.
But HIV virions do not allow for that possibility because the gp160 spikes are too far apart.
Suppressing HIV levels to less than 50 copies/ml significantly diminishes the number of new HIV virions and this profoundly decreases the chance that resistant strains will develop (Spach, 2001).
These particles contain Env anchored to the viral envelope, thus retaining native conformation, and although they neither replicate nor contain the HIV genome, they do closely resemble intact HIV virions (see Figure).
The structure and antigenic repertoire of the DermaVir-expressed proteins and VLP+ are similar to wild-type HIV virions, giving them the ability to induce functional and long-lived HIV-specific immune responses in people living with HIV disease.
In Aphios' vaccine technology, HIV virions are filled with SuperFluids, which are critical, supercritical or near-critical fluids with or without polar cosolvents.