ARNT

(redirected from HIF1B)

ARNT

A gene on chromosome 1q21 that encodes aryl hydrocarbon receptor, which is involved in inducing several enzymes that participate in xenobiotic metabolism—e.g., of dioxin and polycyclic aromatic hydrocarbons—resulting in translocation of the ligand-binding subunit to the nucleus.

Molecular pathology
A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia.
References in periodicals archive ?
The stability of HIF1A is regulated by oxygen level, while HIF1B is constitutively expressed.
In well-studied mammalian systems, the physiological response to hypoxia begins with hypoxia-inducible factor 1 (HIF-1), a transcription factor that is composed of subunits HIF1A and HIF1B (reviewed in Guillemin and Krasnow, 1997).
Molecular mechanisms of transcription activation by HLF and HIF1B in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.