HIF1A

(redirected from HIF-1alpha)

HIF1A

A gene on chromosome 14q23.2 that encodes hypoxia-inducible factor-1 (HIF1), a transcription factor produced by mammalian cells cultured under reduced oxygen tension, which plays an essential role in homeostatic responses to hypoxia, activating the transcription of over 40 genes including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.

HIF1 plays an essential role in embryonic vascularisation, tumour angiogenesis and pathophysiology of ischaemic disease. HIF1 is a heterodimer composed of an alpha subunit (encoded by HIF1A) and a beta subunit (aryl hydrocarbon receptor nuclear translocator) encoded by ARNT.

Molecular pathology
Overexpression of a natural antisense transcript (aHIF) of HIF1A is associated with nonpapillary renal carcinomas.
References in periodicals archive ?
Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma.
Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity.
Gou, "Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications," BMC Cancer, vol.
Instead, the researchers developed a sophisticated protein-tracking technique based on the presence of a hypoxia-responsive protein called Hif-1alpha.
The molecular signaling cascade including phospho-Akt (ser-473) and HIF-1alpha that lead to the activation or suppression of apoptotic pathway also showed a significant protective role in the treatment group.
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia.
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha.
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.
Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression.
Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions.
HIF-1alpha over- expression correlates with tumor aggressiveness, metastases and poor prognosis.