HEY1

HEY1

A gene on chromosome 8q21 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEY1 is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It is expressed in the mesoderm, CNS, kidneys, heart, nasal epithelium and limbs, and it interacts with HES1, HEYL, HDAC1, NCOR1, SIN3A, GATA4, GATA6 and CCDC89/BOIP.
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It is a hardy question, fair sir and Boss, since it doth go far to impugn the wisdom of even our holy Mother Church herself.
Since then, he hath become an active and earnest agitator, a murmurer, and a machinator, and a leader amongst those who impugn our authority; not considering that the rule is given to the Master even by the symbol of the staff and the rod the staff to support the infirmities of the weak the rod to correct the faults of delinquents.
And do not let any one impugn this statement with the trite proverb that "He who builds on the people, builds on the mud," for this is true when a private citizen makes a foundation there, and persuades himself that the people will free him when he is oppressed by his enemies or by the magistrates; wherein he would find himself very often deceived, as happened to the Gracchi in Rome and to Messer Giorgio Scali[+] in Florence.
The contemplative atheist is rare: a Diagoras, a Bion, a Lucian perhaps, and some others; and yet they seem to be more than they are; for that all that impugn a received religion, or superstition, are by the adverse part branded with the name of atheists.
Not being able to impugn her beauty, they attacked her costume.
When he revives he will return to his quarters with a fine tale of his bravery and there will be none to impugn his boasts--none but I-Gos.
It is not for ME'--Mr Podsnap pointed 'me' forcibly, as adding by implication though it may be all very well for YOU--'it is not for me to impugn the workings of Providence.