In Rh-D HDFN grades of DAT were not significantly correlated with risk of peak bilirubin levels, cord blood haemoglobin, disease severity and intensity of treatment.
Antibody titres in mothers of infants with Rh-D HDFN were positively correlated with risk of peak bilirubin levels, severity of disease and intensity of treatment.
Three of the neonates were also tested for bilirubin and two demonstrated elevated bilirubin levels indicating possible cases of HDFN
These observations suggest that the pathogenesis of HDFN
caused by anti-K differs from that due to anti-D.
In mothers of infants with Rh-D HDFN, there were 2 cases of previous blood transfusion (4.
3 times higher risk for moderate and severe anaemia in neonates affected with Rh-D HDFN.
Second, this study did not analyze the reactivity of other clinically significant alloantibodies (eg, Rh, Kell, Kid) implicated in hemolytic transfusion reactions and HDFN
, as these are not included in this PT survey.
HDFN in presence of other illnesses like with twin-to-twin transfusion, high output cardiac failure, infection or sepsis, hereditary spherocytosis, glucose-6-phosphate dehydrogenase deficiency, pyruvate kinase deficiency, [alpha]-Thalassaemia, extravascular blood loss, cephalhaematoma, hypothyroidism, Dubin-Johnson syndrome, cystic fibrosis, biliary atresia, cholestasis, total parenteral nutrition and antibiotic therapy.
While considering the titre of antibodies in mothers of infants with ABO HDFN, only the antibody corresponding to the antigen present in the infant was studied.
All mothers of infants with ABO HDFN were invariably group O; 1 case of previous blood transfusion (0.
Association between neonatal jaundice in siblings and high bilirubin levels in infants with ABO HDFN was assessed using chi-square test.
Among infants admitted in NICU, 158 (6%) had hyperbilirubinaemia due to HDFN
and 182 (7%) had hyperbilirubinaemia due to other causes.