HDAC9

HDAC9

A gene on chromosome 7q21.1 that encodes histone deacetylase 9, a protein with sequence homology to members of the histone deacetylase family and orthologous to Xenopus and mouse MITR genes, the protein product of which lacks a histone deacetylase catalytic domain. MITR represses myocyte enhancer factor-2 (MEF2) activity by recruiting multicomponent corepressor complexes—including CtBP and HDACs. HDAC9 may play a role in haematopoiesis.
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Panobinostat inhibits the activity of a family of proteins including HDAC9.
The primer ser for each gene was followed: histone deacetylase 9 (HDAC9) forward, 5'-GCAAGAGGAGACAGAGACCG-3'; HDAC9 reverse, 5' - ACTTG G C ACTTCAC AAG G CT- 3'; minichromosome maintenance deficient 3 associated protein (MCM3AP) forward, 5'-CGCTTCCTCTGGTGGTTCTT-3'; MCM3AP reverse, 5'CTGCACTGCTTGCAAAACCT-3'; GAPDH forward, 5'-TCACCCACACTGTGCCCATCTATGA-3'; GAPDH reverse, 5'-GAGGAAGAGGATGCGGCAGTGG-3'.
In addition, all compounds affected NF-[kappa]B by regulating HDAC9, MCM3AP, Wilms' tumor 1 (WT1), and Spi-B transcription factor (SP1B) genes in the nucleus.
We quantified the expression levels of HDAC9 and MCM3AP genes because these genes are associated with hepatocarcinogenesis and are directly interacted with NF-[kappa]B (Wang et al.
21 March 2014 - A study, published today in Journal of Biomedical Science, has discovered that single nucleotide polymorphism (SNP) rs10248565 at HDAC9 in chromosome 7p21.
Aberration of SNP rs10248565 at HDAC9 in chromosome 7p21.
27) Bircok kromozomun anomalileriyle birlikte bildirilen bu anomaliyle iliskili genler arasinda PITX2, FOXE3, CYP1B115 ve digenik kalitimla hastaliga neden olan HDAC9 (7p21.
Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly.
Two of the new loci are in or near histone deacetylase genes HDAC4 and HDAC9.
His research is focused on the functions of immune T regulatory (Treg) cells and related roles of Class II HDACs, including HDAC6, HDAC7 and HDAC9.
The researchers discovered an alteration in a gene called HDAC9, which affects a person's risk of large artery ischemic stroke.
The protein produced by HDAC9 is already known to play a role in the formation of muscle tissue and heart development.