HDAC8

HDAC8

A gene on chromosome Xq13 that encodes histone deacetylase 8, which belongs to class I of the histone deacetylase family; it catalyses the deacetylation of lysine residues and represses transcription in large multiprotein complexes with transcription co-repressors.
References in periodicals archive ?
These studies follow the first report of the crystal structure of the enzyme HDAC8 that was published by Celera Genomics in the journal Structure in July 2004.
In a second poster entitled "Specific Inhibition of HDAC8 by Antisense Leads to Growth Arrest and Apoptosis of Human Cancer Cells," (poster #1807), MethylGene presented target-validation data showing that specific inhibition of HDAC8 induces growth arrest and apoptosis in human cancer cells but not in normal cells, in a dose-dependent and time-dependent manner.
The HDAC8 structure was determined using Syrrx's Nanovolume Crystallization(R) technology to crystallize disease-associated proteins.