HDAC3

HDAC3

A gene on chromosome 5q31 that encodes histone deacetylase 3; it belongs to the histone deacetylase/acuc/apha family, which represses transcription when tethered to a promoter and may regulate transcription by binding with the zinc-finger transcription factor YY1. HDAC3 downregulates p53 activity and thus modulates cell growth and apoptosis; it may be a tumour suppressor gene.
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The stiffness is caused by a 'molecular brake pad' called HDAC3 which has become 'overeager' in compacting the DNA.
The fluorescent intensities of MRP2 in the control, HDAC2, and HDAC3 siRNA-transfected cells were week, and no significant differences were noticed among these three groups (all P > 0.
Bartling y colaboradores [24] informaron respecto a aumentos en los niveles de HDAC3 en cancer de pulmon escamo celular, y Minamiya y colaboradores [25] resportaron sobrexpresiones de HDACI y HDAC3 en pacientes con adenocarcinoma pulmonar.
HBI-8000 inhibits cancer-associated Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10 at nanomolar concentrations and stimulates accumulation of acetylated histones H3 and H4 in tumor cells.
Shen, "NF-[kappa]B/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK," Biochimica et Biophysica Acta--Molecular Cell Research, vol.
We used the following plasmids for transfections: HDAC1 (plasmid 13820), HDAC3 (plasmid 13819), and HDAC4 (plasmid 13821; all from Addgene).
David Artis PhD, associate professor of Microbiology, and colleagues report that the enzyme HDAC3 is a key mediator in maintaining proper intestinal integrity and function in the presence of friendly bacteria.
In 2011, Wood's group deleted the HDAC3 gene in a small group of hippocampal neurons in mice.
Recent studies also have shown that liver-specific knockout of the gene encoding HDAC3 in mice leads to severe hepatic steatosis and increased expression of lipogenic genes, although whether HDAC3 expression or function is altered by ethanol has yet to be elucidated (Sun et al.
NF-KB/p65 antagonizes Nrf2ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK.
Wood, which demonstrates that one of Repligen's HDAC3 inhibitors improves both the acquisition and persistence of long-term memory in an animal model.
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.