HDAC1

HDAC1

A gene on chromosome 1p34 that encodes histone deacetylase 1, which belongs to the histone deacetylase/acuc/apha family and is a part of the histone deacetylase complex. It interacts with retinoblastoma tumour-suppressor protein and controls cell proliferation and differentiation. With metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
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1 HDAC1 115 forward histone deacetylase 1 reverse XM_004016118 TPH1 128 forward tryptophan reverse hydroxylase 1 NM_173907.
These include programs in multiple indications for the orally bioavailable, HDAC6 selective inhibitor, ricolinostat (ACY-1215) and the company's HDAC1 inhibitor programme in orphan blood disorders such as sickle cell disease and beta-thalassemia.
Regenacy will receive exclusive worldwide rights to Acetylon's Phase 2 selective histone deacetylase 6 (HDAC6) inhibitor, ricolinostat (ACY-1215), for the treatment of certain non-cancer disease indications including neuropathies, as well as Acetylon's preclinical selective HDAC1,2 inhibitor candidates and patent families for development in all human disease indications including sickle cell disease and beta-thalassemia.
Zuo Y, Qiang L, Farmer SR (2006) Activation of CCAAT/enhancer-binding protein (C/EBP) a expression by C/EBPp during adipogenesis requires a peroxisome proliferator-activated receptor-[gamma]-associated repression of HDAC1 at the C/ebpa gene promoter.
HBI-8000 inhibits cancer-associated Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10 at nanomolar concentrations and stimulates accumulation of acetylated histones H3 and H4 in tumor cells.
As shown in Figure 3, we found that the expression of histone acetyltransferase CREBBP in LADA patients was downregulated compared to healthy controls (Figure 3(a), the absolute of fold change > 2 was considered significant), and the expression of histone deacetylases HDAC1 and HDAC7 was upregulated (Figure 3(b)).
Coordination between the inhibition of HDAC1 and the activation of the histone demethylase lysine-specific demethylases (KDM6b/JMJD3a) and KDM6a/UTX activates brown adipocyte genes and prevents the appearance of obesity [110, 111].
Consistent with the molecular interaction between maspin and nuclear HDAC1, in benign prostate epithelium, maspin is localized predominantly in the nuclei of basal cells, whereas in high grade prostatic intraepithelial hyperplasia (high-grade prostatic intraepithelial neoplasia (HGPIN), maspin expression is significantly increased and is translocated to the cytoplasm.
The binding of the AHR to the Il-6 promoter results in jettison of HDAC1 (histone deacetylase 1) from the promoter, leading to increased NF-[kappa]B (nuclear factor-[kappa]B) occupation and acetylation.
For example, the histone deacetylase HDAC1 has been shown to play a critical role in the silenced expression in HSCs of the fibrosis-attenuating protein BAMBI (see figure 4) (Liu et al.
Mutant p53 binds to estrogen receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast cancer cells.