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The company, which spun-out from the University in 2005, was created to develop a new family of highly potent, optimized HDAC inhibitors that were identified by the University of Southampton and Cancer Research UK.
Preclinical and clinical data support the use of HDAC inhibitors in lymphoma.
We are pleased to be working together with TopoTarget, a leader in the HDAC field.
Another mystery is why diverse proteins are attached to the HDAC/BHC110 core, in contrast to the other HDACs, which bind only one type of protein to their cores.
The HDAC inhibitor might be paired with experimental treatments that reduce protein aggregation in cell nuclei, he says.
Previous studies suggested that non-specific HDAC inhibitors were successful in inducing HbF, however, their development has been delayed due to concerns over variable efficacy and off-target side-effects.
Several substances inhibiting so-called HDAC enzymes have been studied in trials in recent years.
com)-- Current HDAC assay kits have been based on a short wavelength substrate whose detection is darkened by the presence of autofluorescence interference.
Both pharmacokinetic evaluations and the measurement of HDAC activity in peripheral white cells demonstrated a dose-dependent effect.
Thompson's group theorized that such drugs, called HDAC inhibitors, also might counteract the gene disruptions caused by glutamineladen proteins.
Description: These are the first results to indicate that a selective HDAC inhibitor can have marked activity across a panel of lymphoma cell lines.
Chidamide is an orally bioavailable, low-nanomolar inhibitor of cancer-associated histone deacetylase (HDAC) enzymes with favorable pharmacology and tolerability profiles relative to existing benzamide and non-benzamide HDAC inhibitors.
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