HDAC


Also found in: Acronyms.

HDAC

high-dose
cytarabine.
(a chemotherapeutic agent to treat acute myelogenous leukemia.
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An official at the exchange said HDAC tokens would be exchangeable with other types of digital tokens such as bitcoin.
HDAC are enzymes that remove acetyl groups from lysine amino acids on histones, and it is thought that by inhibiting HDAC to allow acetyl groups to accumulate on histones and relax chromatin structures promotes gene transcription activity.
The company, which spun-out from the University in 2005, was created to develop a new family of highly potent, optimized HDAC inhibitors that were identified by the University of Southampton and Cancer Research UK.
PXD101 is a promising small molecule HDAC inhibitor being investigated for its role in the treatment of a wide range of solid and hematologic malignancies either as a single-agent, or in combination with other active anti-cancer agents, including 5-fluorouracil (5-FU), carboplatin, paclitaxel, cis-retinoic acid and Velcade(r) (bortezomib) for Injection.
The HDAC section of the new complex binds to chromatin to shut off genes, just like all other HDACs; the challenge lies in uncovering what the BHCllO component does.
and British colleagues added an HDAC inhibitor called suberoylanilide hydroxamic acid to the drinking water of young mice genetically engineered to make mutated huntingtin protein.
HDAC Inc, an Alameda, California-based electronic design automation tools company, has launched what it calls the industry's first static functional verification tool.
This program adds to our broadening pipeline of targeted epigenetic drugs and is yet another example of the wide array of human disease indications for which selective HDAC inhibitors hold promise.
The product is an oral HDAC inhibitor approved in China for use in the treatment of peripheral T-cell lymphoma.
Several substances inhibiting so-called HDAC enzymes have been studied in trials in recent years.
com)-- Current HDAC assay kits have been based on a short wavelength substrate whose detection is darkened by the presence of autofluorescence interference.