HTT

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HTT

A gene on chromosome 4p16.3 that encodes huntingtin, a protein thought to play a role in microtubule-mediated transport or vesicle function.
 
Molecular
Pathology HTT mutations are linked to Huntington’s disease.
References in periodicals archive ?
Davidson in animal models of HD have demonstrated that siRNAs targeting the messenger RNA for the mutant HD protein are able to attack the fundamental cause of HD and reduce the protein expression from the disease gene.
The study reported a significant reduction in the disease-causing HD protein in mice and a significant improvement in the motor functions and neurological abnormalities associated with the disease.
Results also demonstrated that levels of toxic HD protein in siRNA treated mice were reduced to 40 percent of normal levels.
It is very exciting that a partial reduction in the HD protein is sufficient to produce a very beneficial effect in the animal.
The study also demonstrated that levels of toxic HD protein in siRNA treated mice were reduced to 40 percent of normal levels.