HCN4

HCN4

A gene on chromosome 15q24.1 that encodes a member of the hyperpolarisation-activated cyclic nucleotide-gated potassium channels, which has slow activation and inactivation kinetics, and is critical in cardiac pacemaking. HCN4 may mediate responses to sour taste stimuli.

Molecular pathology
HCN4 mutations are linked to sick sinus syndrome 2—e.g., atrial fibrillation with bradyarrhythmia or familial sinus bradycardia.
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Actually the heart's pacemaker changes in response to training and in particular there is a decrease in an important pacemaker protein, known as HCN4, and this is responsible for the low heart rate," she added.
Because a related gene called HCN4 plays a critical role in controlling electrical activity in the heart, McNaughton's team suspected that HCN2 might have a similar function and regulate electrical activity in pain-sensitive nerves.