HCN4

HCN4

A gene on chromosome 15q24.1 that encodes a member of the hyperpolarisation-activated cyclic nucleotide-gated potassium channels, which has slow activation and inactivation kinetics, and is critical in cardiac pacemaking. HCN4 may mediate responses to sour taste stimuli.

Molecular pathology
HCN4 mutations are linked to sick sinus syndrome 2—e.g., atrial fibrillation with bradyarrhythmia or familial sinus bradycardia.
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Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4.
However, THSG treatment increases the percentage of the S-phase in sorted c-kit(+) rat cardiac stem cells and promotes expressions of PCNA, VEGF, the T-box transcription factor, hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2), HCN4, the a myosin heavy chain, [beta] myosin heavy chain mRNA, stem cell antigen 1, cardiac troponin-I, GATA-4, Nkx2.
Association of polymorphis ms in HCN4 with mood disorders and obsessive compulsiv e disorder.
D'Souza A (1) et al supported in their study that training-induced bradycardia is not a consequence of changes in the activity of the autonomic nervous system but is caused by intrinsic electrophysiological changes in the sinus node so concluded Exercise training reduces resting heart rate via down regulation of the funny channel HCN4.
Actually the heart's pacemaker changes in response to training and in particular there is a decrease in an important pacemaker protein, known as HCN4, and this is responsible for the low heart rate," she added.
Because a related gene called HCN4 plays a critical role in controlling electrical activity in the heart, McNaughton's team suspected that HCN2 might have a similar function and regulate electrical activity in pain-sensitive nerves.