HSPCs express at least 1 P-selectin (sP) ligand, sP glycoprotein ligand-1 (PSGL-1/CD162), and another selectin ligand, HCELL (15, 16) Primitive [CD34.
The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing.
The certification aspects of this core were developed by HCELL
Engineering using Mentor tools.
Differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL
HCELL is a specific sugar (carbohydrate) modification of CD44.
The presence of the HCELL molecule on the cell surface allows blood- forming stem cells to migrate or "home" to the bone marrow.
Understanding the biology of HCELL has great implications for the development of novel therapies for leukemias, and for accelerating blood cell production following bone marrow transplantation," said Dr.
Altera, together with Aldec, Geensys, HighRely and HCELL
Engineering, provide a comprehensive environment of DO-254-certifiable intellectual property (IP) cores, in-hardware verification flows and documentation.
Altera Corporation (NASDAQ:ALTR) and HCELL Engineering today announced the development of a safety-critical version of Altera's Nios([R]) II embedded processor.
HCELL Engineering will provide complete DO-254 certification for the safety-critical Nios II embedded processor, including source code and documentation such as a PHAC-plan for hardware certification, a hardware design document (HDD) and a hardware accomplishment summary (HAS).
Altera and HCELL Engineering worked closely with Thales Aerospace to validate this safety-critical version of the Nios II embedded processor within its latest avionics system.
Altera and HCELL Engineering have made all the necessary efforts to understand the objectives and requirements of DO-254 in order to deliver a safety-critical version of the Nios II embedded processor.