FZR1

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FZR1

A gene on chromosome 19p13.3 that encodes a key regulator of ligase activity of the anaphase-promoting complex/cyclosome (APC/C), conferring substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis (in place of CDC20) and activates the APC/C during anaphase and telophase. The APC/C degrades the substrate to ensure that cell cycle upregulators do not accumulate prematurely; at the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. FZR1 is highly expressed in the heart, liver, spleen, and in some cancer cell lines.
References in periodicals archive ?
High concentrations of acetyl-CoA in the liver may have inhibited fatty acid [beta]-oxidation, so that expression of HCDH was decreased.
Parmi les 149 Etats parties au Pacte de 1966, seuls 104 sont egalement parties au premier protocole (Haut-Commissariat des Nations Unies aux droits de l'homme (HCDH), Statut des instruments internationaux relatif aux droits de l'homme (2003), en ligne: HCDH <http://www.
Le HCDH a aussi exhorte le gouvernement du Nigeria, qui a annonce le deploiement de forces militaires supplementaires dans les bastions du groupe Boko Haram au nord du pays, a respecter les principes des droits de l'Homme, notamment lors des patrouilles et des operations d'urgence.
beaucoup moins que]Nous appelons le gouvernement nigerian a s'assurer que ses efforts pour retablir la securite soient conformes aux principes des droits de l'homme[beaucoup plus grand que], a demande le porte-parole du HCDH, Rupert Colville.