KAT7

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KAT7

A gene on chromosome 17q21.32 that encodes a component of the HBO1 complex which is responsible for the bulk of histone H4 acetylation. KAT7 specifically represses AR-mediated transcription; it may regulate DNA replication by chromatin acetylation and act as a coactivator of TP53-dependent transcription.
References in periodicals archive ?
1999) Histone acetyl transferase HBO1 interacts with the ORC1 subunit of the human initiator protein.
2011) HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.
2010) HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
2008) FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication.
6 m) 700-L mesocosms at HBO1 were supplied with ambient seawater from the IRL at a flow rate of 10 L/min, and were aerated to maintain high dissolved oxygen levels (Table 1) and to keep seston in suspension.
Bewkes oversees a domestic operation that includes four HBO channels - HBO1, HBO2, HBO3 and HBO Family - and three channels of its sister net Cinemax.
I]t is the intent of the Committee that `multiplexed' premium services such as HBO1, HBO2, and HBO3 also be excluded from the term `cable programming service.