FGF2

(redirected from HBGF-2)

FGF2

A gene on chromosome 4q26 that encodes fibroblast growth factor 2 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration. FGF2 plays a key role in various processes, including limb and nervous system development, wound healing and tumour growth, as well as angiogenesis. It is expressed in normal ovarian tissue and in hepatocellular carcinoma, but not in normal liver cells. FGF2 interacts with FGF receptors FGFR1, -2, -3 and -4.