USP7

(redirected from HAUSP)
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USP7

A gene on chromosome 16p13.3 that encodes an enzyme which deubiquitinates target proteins (e.g., FOXO4, p53/TP53, MDM2, PTEN and DAXX). USP27 forms a complex with DAXX, MDM2 and RASSF1. It is widely expressed in various tissues and overexpressed in prostate cancer.
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The peptides derived from this viral protein bind 200 times more strongly to HAUSP than p53, making them ideal HAUSP inhibitors.
The researchers found that the peptides comprehensively prevented HAUSP from cleaving ubiquitin, allowing p53 levels to rise - thereby representing potential new chemotherapeutic molecules that can be used for anti-cancer therapies.