PYCARD

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PYCARD

A gene on chromosome 16p11.2 that encodes an adaptor protein  composed of two protein–protein interaction domains: an N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD), both of which belong to the six-helix bundle death domain-fold superfamily. This superfamily mediates assembly of large signalling complexes in the inflammatory and apoptotic-signalling pathways by activating caspase. In normal cells, PYCARD localises to the cytoplasm, but in cells undergoing apoptosis it forms ball-like aggregates near the nucleus.
References in periodicals archive ?
The HASC recently passed its 2017 NDAA, calling for a $583 billion hike in spending, including such line items as 11 more F-35s and a $2 billion boost to the Navy's shipbuilding budget.
Not surprisingly, Representative Cramer was also a member of the HASC and showed keen interest in space and missile defense programs for his district.
Since initial planning for the C-27J relied heavily on aviation assets of the Army National Guard, we should capture that expertise--following a suggestion by the HASC report--as an "Army to Air Force" resource.
HASC, Seapower Committee, Force Structure Impacts on Fleet and Strategic Lift Operations, 13 October 1999, 6.
1993) [hereinafter HASC Hearing]; Assessment of the Plan to Lift the Ban on Homosexuals in the Military,: Hearings Before the Subcomm.
The HASC held a series of hearings to examine the future role of the military, including what criteria we should use in order to decide where, when, and how to use military force.
Another powerful group of civilian elites is comprised of Members of Congress, especially those from committees that provide oversight--the Senate Armed Services Committee and House Armed Services Committee (SASC and HASC, respectively)--along with those Members who are responsible for resourcing decisions through their respective congressional defense appropriations committees.
The legislation seeks to ensure that we do not deploy troops who are not fully trained, whose equipment is worn out and who did not get the resources they needed back home to be ready to face our enemies overseas," HASC Chairman Rep.
Attributing the problem to cumbersome bureaucratic processes, HASC stated its expectation that the departments "begin exercising the authority in a timely manner.
Selina Lund So again they are saying this is for financial reasons but are now advertising HASC old time slot at PS1 - we were charged far more for the hire.
Sgt Jones and Det Sgt Hinton have also been called to appear before the HASC for a second time tomorrow, after being accused of giving "misleading" answers to MPs on October 23.
Calderone is a member of the Hospital Association of Southern California (HASC) and has been voted Chair-Elect by the HASC Executive Committee.