PYCARD

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PYCARD

A gene on chromosome 16p11.2 that encodes an adaptor protein  composed of two protein–protein interaction domains: an N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD), both of which belong to the six-helix bundle death domain-fold superfamily. This superfamily mediates assembly of large signalling complexes in the inflammatory and apoptotic-signalling pathways by activating caspase. In normal cells, PYCARD localises to the cytoplasm, but in cells undergoing apoptosis it forms ball-like aggregates near the nucleus.
References in periodicals archive ?
For this Comprehensive Regional Security Strategy Report, the appropriate congressional committees include both the HAC and SAC, both the HASC and SASC, the SFRC, the HFAC, the House Permanent Select Committee on Intelligence, and the Senate Select Committee on Intelligence.
House, Joint Cargo Aircraft Force Structure Requirements and Basing Plan; HASC Committee Report to Accompany H.
4) Again, this HASC chairman's tasking focused the purpose of JPME on joint command and staff competence.
The HASC will likely approve an extension but seek to keep the funding level at $100 million and reduce the time limit to two years.
He served as the deputy staff director and the assistant deputy staff director for the House Armed Services Committee; staff director of the HASC Subcommittee on Military Installations and Facilities; the subcommittee professional staff member for the HASC Subcommittee on Oversight and Investigations; professional staff member for the Joint Committee on the Organization of Congress; and legislative assistant to U.
While sympathising with the ``unenviable task'' officers faced, the HASC was critical of so-called trawling inquiries, including South Wales' Operation Goldfinch.
It was then that the couple decided to join the HASC.
Nestled among the cool mountains of New York's Catskills, surrounded by verdant fields, the HASC Summer Program is no ordinary summer camp.
HASC will again proudly co-host the Health Care Provider Wellness Conference," said Teri Hollingsworth, vice president, Human Resources Services, HASC.
But Mr Greenhalgh said: "I am not optimistic about KAL having anything that they can do to help HASC as they are insisting that Sunday 6pm to 8pm is the only time they can give the club.
The HASC recently sent an analysis to the conferees that detailed a loss of 100,000 troops with continued sequestration, a Navy of 230 ships, the smallest Air Force ever and the leanest ground forces since 1940.