FBXW7

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FBXW7

A gene on chromosome 4q31.3 that encodes a so-called F-box protein, which contains a 40 amino acid protein-interacting motif (the F box). F-box proteins form a complex with SKP1 and cullin, resulting in phosphorylation-dependent ubiquitination and ubiquitin-mediated degradation of targeted proteins. F-box proteins are divided into three classes based on the presence of:
(1) WD-40 repeats—as is the case with this F-box protein (Fbws class),
(2) leucine-rich repeats (Fbls class); or
(3) the presence or absence of other protein-protein interacting domains (Fbxs class).
The FBXW7 protein product binds directly to cyclin E, targeting it for ubiquitin-mediated degradation.

Molecular pathology
FBXW7 mutations are found in ovarian and breast cancer cell lines, implicating FBXW7’s potential role in carcinogenesis.
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References in periodicals archive ?
Hagos this time had to settle for second place over 10m behind Swinburn.
30pm on August 4 Miss Hagos walked from St Thomas' Church in Thornton Lodge towards Church Street in Paddock and she saw Tekeste.
Ethiopia's Hagos Gebrhiwet won the race in a world junior record of 7:32.
Doran has an extensive manufacturing background experience and will support Hagos with the day-to-day restaurant operations.
Haben Hagos of Beverly Hills (4-6) scored 15 points, 12 in the second half.
Hagos Reda, 43, is one of three farmers who formed a co-operative with 20 chickens each from a Trocaire cwc fr project.
Wallsend's Yared Hagos won the Leicester Half-Marathon in 67:35.
He was ably supported by Yared Hagos of Wallsend (18th), Lewis Timmins of Morpeth (26th), Ben Douglas of Durham (39th) and Matt Nicholson of Morpeth (42nd) as the North East held off the challenge of Middlesex and Surrey.
The double Olympic champion was a straightforward winner at the European Team Championships at Gateshead last week but faced a much stiffer challenge at Alexander Stadium, with the world's two fastest men over the distance - Ethiopian pair Yenew Alamirew and Hagos Gebrhiwet - on the start line.
Tedros Hagos Berhanu, 19, of Pearl Street, Cardiff, admitted drunk and disorderly behaviour and assaulting an officer in the execution of her duty.
Close behind were Morpeth's Nick McCormick having his first race of the season and Yared Hagos of Wallsend.