H3 receptor antagonists

H3 receptor antagonists

Drugs that block H3 receptors in the central nervous system. Such drugs may be used to treat disorders of sleep and arousal, wakefulness, and attention.
References in periodicals archive ?
Furthermore, preclinical and clinical studies are currently investigating the potential use of the H3 receptor antagonists for the treatment of cognitive disorders such as Alzheimer's disease (6,7).
Effects of histamine H3 receptor antagonists in two models of spatial learning.
Evotec said today that it has successfully identified and optimised H3 receptor antagonists through to preclinical development.
H3 receptor antagonists have the potential to become an important new class of therapy in a number of CNS indications, including excessive fatigue associated with conditions such as multiple sclerosis.
5m grant for H3 receptor antagonist programme(C)2010 M2 COMMUNICATIONS http://www.
Ziarco's pipeline includes a histamine H4 receptor antagonist programme, with a lead compound that has completed a Phase 1 multiple ascending dose study; a clinical stage cytosolic phosholipase A2 (cPLA2) inhibitor; histamine H3 receptor antagonists possessing CNS-sparing properties, with a lead compound in advanced preclinical development; as well as early-stage spleen tyrosine kinase (SYK) inhibitor molecules suitable for topical administration.
The pipeline is completed by a histamine H3 receptor antagonist programme possessing CNS-sparing properties which is in advanced preclinical development and an early-stage spleen tyrosine kinase (SYK) inhibitor programme suitable for topical administration.