AKAP5

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AKAP5

A gene on chromosome 14q21-q24 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunit of protein kinase A (PKA), confining the enzyme to discrete locations within the cell. AKAP5 binds to the RII-beta regulatory subunit of PKA, as well as to protein kinase C and the phosphatase calcineurin. It is primarily expressed in the cerebral cortex, may anchor the PKA protein at postsynaptic densities (PSD) and be involved in regulating postsynaptic events; it is also expressed in T cells and may inhibit IL-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
References in periodicals archive ?
One milliliter cultures of WT, CF9, CV13, CV14, H19, H20, and H21 were grown aerobically overnight and diluted to [A.
67%) is obtained when the members of the main corpus are the individual papers in H-IV (H8, H28, H68, H21, H67, H85) and M-III (M10, M14, M37, M41, M42, M43, M47, M48, M58), but it rises to 62.
Only the H21 and H24 hypotheses' moderating effects are significant, which means that communication dilutes their initial effects in a statistically significant fashion.
Finally, H20 and H21 state that after successful implementation of JIT, organizations are able to design new products with less development cost and less manufacturing cost.
Models H21 and H24 high-pressure valves have a redesigned guide pin that provides high sealability at lower cost.
They referred the matter on to the Jockey Club, who will examine Rigmarole's withdrawal under Instruction H21, 'Withdrawal of Top Weights', which may result in a veterinary examination of the horse.
Series 20 valve models H21 and H24 have a redesigned guide pin that provides high sealing ability at a lower cost.
H21 and H91 are ideal substrates for both PVD and CVD coatings.
Si su actitud es sospechosa, mas lo es el radiograma que Kalle envia al jefe del espionaje germano en Holanda, dandole instrucciones de que remita a la Oficina de Pagos de Paris la cantidad, nada desdenable, de quince mil pesetas, que se han de entregar al agente H21.
Se le dio matricula H21 y durante un ano completo permanecio en Paris casi sin hacer nada.