AKAP5

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AKAP5

A gene on chromosome 14q21-q24 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunit of protein kinase A (PKA), confining the enzyme to discrete locations within the cell. AKAP5 binds to the RII-beta regulatory subunit of PKA, as well as to protein kinase C and the phosphatase calcineurin. It is primarily expressed in the cerebral cortex, may anchor the PKA protein at postsynaptic densities (PSD) and be involved in regulating postsynaptic events; it is also expressed in T cells and may inhibit IL-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
References in periodicals archive ?
One milliliter cultures of WT, CF9, CV13, CV14, H19, H20, and H21 were grown aerobically overnight and diluted to [A.
Mutants H19, H20, and H21 hyper producers produced more violacein than WT as seen by higher absorbance at 585 nm.
The service and maintenance of H21 blocks is currently being managed by FCHO Officers and will remain as such until December, 2013 at this stage FCHO are not in a position to comment on the future procuremen
H antigens associated with O91 were H8 (n = 1), H10 (n = 2), H14 (n = 52), H21 (n = 20), Hnt (H-antigen nontypeable) (n = 10), and H- (H-antigen nonmotile) (n = 15).
2] 0 0/2 :meaningfulness0/048 :Doorbin-Vatson 8-Jan Table 4: The results of test thesis H21.
W/W* Darcy Burner, WA, H08 W/* Francine Busby, CA, H50 L Russ Carnahan, MO, H03 W/W John Courage, TX, H21 W/L Peter Goldmark, WA, H05 W/L Larry Grant, ID, H01 W/L Paula Hollinger, MD, H03 Lp Hank Johnson, GA, H04 W/W Ember Reichgott Junge, MN, H05 Lp Ron Kind, WI, H03 W/W Patricia Madrid, NM, H01 W/TC* Jim Marcinkowksi, MI, H08 W/L Jerry McNerney, CA, H11 W/W* Ellen Simon, AZ, H01 W/L Louise Slaughter, NY, H28 W/W Tim Walz, MN, H01 W/W* Patty Weiss, AZ, H08 Lp Janet Napolitano, AZ, Gov.
They automatically referred the matter to Portman Square under Instruction H21 `Withdrawal of Top Weights', but the Jockey Club is not expected to take any action against Nicholls.
Users can simply plug the sensor into an Onset HOBO([R])U30 or H21 Weather Station and begin monitoring without having to spend time wiring or programming.
These grades (AISI H12, H13, H21, and H42) are typically low in carbon with high percentages of alloying elements, particularly chronium, with varying amounts of molybdenum, tungsten, vanadium, and silicon.
An inquiry was held at Cheltenham under instruction H21, which deals with the withdrawal of top-weights in Class A or B handicaps over jumps.
Samples were drawn by routine venipuncture and processed for platelet poor plasma within 4 hours of collection adhering to CLSI H21 A5 Collection guidelines.