CD59

(redirected from H19)

CD59

a glycosylphosphatidylinositol-anchored membrane protein present on many hemopoietic cells, vascular endothelium, epithelial cells, and placenta that inhibits membrane complement attack and may be involved in T-cell signal transduction; absent or defective in paroxysmal nocturnal hemoglobinuria.

CD59

A 65-kD membrane, glycosyl-phosphatidylinositol-anchored complement-neutralising protein encoded by CD59 on chromosome 11p13, which inhibits the complement membrane attack complex, binding to C8 and C9 during assembly of the complex.

Normal expression
Most leukocytes and red cells.

Abnormal expression
May be absent in some forms of paroxysmal nocturnal haemoglobinuria.
References in periodicals archive ?
A study analyzed the overexpression of H19 in human trophoblasts and detected the cell proliferation with CCK-8 technology.
The maternally expressed long noncoding H19 RNA and the methyl-CpG-binding protein Mbd1 form a complex that regulates multiple imprinted genes by interacting with histone lysine methyltransferases.
In 1991, the first three imprinted genes, Insulin-like growth factor 2 (Igf2), Insulin-like growth factor 2 receptor (Igf2r) and H19, imprinted maternal expressed transcript (H19) were identified.
In this study, we have examined the allelic counts of 2 RNA transcripts, namely pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) (5), a pregnancy-specific gene, and H19, imprinted maternally expressed transcript (non-protein coding) (H19), an imprinted maternally expressed gene (27, 28).
Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects".
BC-821 is a potential therapeutic product that penetrates cancerous cells and activates the synthesis of DTA under the control of H19 and /or P4 promoter of the target gene IGF2.
El mayor GHI lo tuvieron los machos MI, M2, M5 y M9, y las hembras H14, H19 y H18; es de resaltar que tres de los machos (M2, M5 y Mil) tambien tuvieron la LMZ mas larga.
For the current study, the Stowers researchers focused on a differentially imprinted control region, which drives the reciprocal expression of H19 from the maternal allele and Igf2 (Insulin growth factor 2) from the paternal allele.
violaceum mutants H19, H20 and H21 expressed moreviolaceum than WT, and were considered hyper producers.
The sprouts used to obtain the mini-cuttings originated from Eucalyptus benthamii x Eucalyptus dunnii mini-stumps (clones H12, H19 and H20) (Figure 1A), grown in a semi-hydroponic system of the 'canaletao' (gutters) type, containing medium sand.
The objective of this study was to evaluate the effects of different spacing's between or within rows on the agronomic characteristics of three genotypes of Brassica napus new lines (crossed two varieties of H19, goliath), Zarfam and were Pahnab-ejoybar(Local varieties).
Of these genes, only 10 genes have been reported to show imprinting in sheep (GTL2, DLK1, DAT, PEG11, antiPEG11, MEG8, MEST, IGF2, H19 and IGF2r; Killian et al.