Pre-treatment with an H1-receptor
antagonist or prolonged infusion can prevent the ADR.
The participants followed a twice daily treatment of GSP 301, mometasone (a corticosteroid), olopatadine (a histamine H1-receptor
agonist) or placebo for 14 days.
In addition to the newly acquired Heprotect compounds, Elorac's development pipeline includes: naloxone lotion for treatment of pruritus accompanying cutaneous T-cell lymphoma, a product with orphan drug and fast-track designations from the US Food and Drug Administration; cidoxepin, a highly potent histamine H1-receptor
antagonist being developed for relief of chronic urticaria; and a once-weekly tablet for nodulocystic acne.
Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness and brain histamine H1-receptor
occupancy using 11C-doxepin positron emission tomography.
During the past 8 years she had been classified as having appendicitis pancreatitis ischemic enteropathy or irritable bowel syndrome and treated with H1-receptor
antagonists glucocorticoids cholinoceptor blocking drugs etc.
Intra-vermal cerebellar administration of chlorpheniramine, an H1-receptor
antagonist, prior to histamine infusion, significantly reduced open-arm exploration compared with a group that was microinjected with histamine only, indicating possible involvement of this receptor in histamine-induced memory impairment in mice (20).
An orally active and selective H1-receptor
antagonist currently prescribed in over 100 countries worldwide, Zyrtec shows significant antiallergic effects with a once-a-day dosage.
Pregnant women with pruritus should have repeated measurement of serum bile acids with expectant management when the level is below 40 mmol/L and control of symptoms with H1-receptor
blockers or ursodeoxycholic acid, the investigators suggested (Hepatology 2004;40:467-74).
Betahistine is a small molecule drug that acts as a partial histamine H1-receptor
agonist and a H3-receptor antagonist.
12,13,14) The anti-inflammatory activities of second- and third-generation H1-receptor
antagonists have been evaluated in vitro.
According to the company, AtoKin is a beef-flavoured, chewable, high-dose, second generation histamine H1-receptor