Intra-vermal cerebellar administration of chlorpheniramine, an H1-receptor
antagonist, prior to histamine infusion, significantly reduced open-arm exploration compared with a group that was microinjected with histamine only, indicating possible involvement of this receptor in histamine-induced memory impairment in mice (20).
Efficacy and tolerability of once-daily 5mg desloratadine, and H1-receptor
antagonist, in patients with seasonal allergic rhinitis: assessment during the spring and fall allergy seasons.
An orally active and selective H1-receptor
antagonist currently prescribed in over 100 countries worldwide, Zyrtec shows significant antiallergic effects with a once-a-day dosage.