ATP6V1A

(redirected from H+-transporting ATPase chain A, vacuolar)

ATP6V1A

A gene on chromosome 3q13.31 that encodes a subunit of H+-ATPase (also known as V-ATPase, vacuolar ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles, which is required for an array of molecular processes, including protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation.