To the Editor: In 2011, a chicken anemia virus (CAV)-related sequence, designated avian gyrovirus 2 (AGV2), was first identified in serum samples from diseased chickens in Brazil (7).
The 12 AGV2 sequences we identified clustered together with gyrovirus sequences detected in ferret and human samples in subgroup I, and the prototype sequence Ave3 was located in subgroup II.
Discovery of a genome of a distant relative of chicken anemia virus reveals a new member of the genus Gyrovirus.
Identification of the first human gyrovirus, a virus related to chicken anemia virus.
genus consists of the chicken anemia virus, which shares no significant genotypic similarity with BFDV.
Two genera, Circovirus and Gyrovirus
, are recognized, and an additional genus, Cyclovirus, has been proposed (1,2).
The family Circoviridae is currently composed of 2 genera, Gyrovirus
and Circovirus, each of which has been associated with diseases in birds, pigs, and dogs (1,2).
Chicken anemia virus (CAV), initially the sole member of the genus Gyrovirus
(family Circoviridae), possesses a genome of [approximately equal to] 2.
Circoviruses are nonenveloped, spherical viruses with a single-stranded circular DNA genome of [approximately equal to] 2 kb; they group as a genus within the family Circoviridae, together with the proposed genus Cyclovirus and the phylogenetically more distinct genus Gyrovirus
reported the discovery of a novel virus in human skin specimens and named it human gyrovirus (HGyV) (1).
The finding is not totally unexpected because CAV and the recently discovered avian gyrovirus 2, a virus genetically similar to HGyV, can circulate in the blood of infected animals (15-18).
Prevalence of human gyrovirus DNA in 251 HIV-positive or transplant recipient patients and 50 blood donors, Italy Material No.